A novel technique to enhancing the bioavailability of Itraconazole using freeze drying
The aim of the present work was to develop a Itraconazole freeze dried tablet (FDT). Which dissolve instantaneously in the mouth. To enhancing the bioavailability of poorly water-soluble Itraconazole was improved by preparing a FDT of Itraconazole using freeze-drying technique. The FDT was prepared by dispersing the drug in an aqueous solution of highly water-soluble carrier materials consisting of gelatin, glycine, and sorbitol. The mixture was poured in to the pockets of blister packs and then was subjected to freezing and lyophilization. The FDT was characterized by DSC, XRD and SEM and was evaluated for saturation solubility and dissolution and compared with physical mixture (PM) and pure drug. The samples were stored in stability chamber to investigate their physical stability for 90 days. Result obtained by DSC and X-ray studied showed that Crystalline state of Itraconazole in FDT transformation to amorphous state during the formation of FDT. SEM result suggests reduction in Itraconazole particle size. The solubility of Itraconazole from the FDT showed seven times greater than pure drug was due to super-saturation generated by amorphous form of the drug. Dissolution studies showed that dissolution rate of FDT of Itraconazole significantly improved compared with the PM and the pure drug. More than 90% of Itraconazole in FDT dissolved within 5 min compared to only 27.38% of Itraconazole pure drug dissolved during 60 min. In stability test, the dissolution release profile of the Itraconazole in FDT was almost unchanged as compared with the freshly prepared FDT.
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A rare and voluminous cervical tumor (a case report and literature review)
Fusiform cell lipomas are rare adipocytic tumours characterized by proliferation of mature adipocytes and fusiform cells; we report the case of a 59-year-old patient who received surgical removal from a left cervical tumor whose anatomopathological examination returned in favor of a fusiform cell lipoma.
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A Review Paper on Lead Exposure and Poisoning in Nigerian Children: The way forward
Nigerian Children are still exposed to lead from the environment, food, drinking water, cosmetics, parents’ occupation, and the use of residual lead painted woods. Although, lead poisoning outbreak in Zamfara and Kaduna which claimed the life of several children, occurred in villages and amidst the lower societal class. Recent studies have however revealed that lead exposure is still a prevalent issue in urban and rural areas with the continued production of leaded paint by the Nigerian paint industries, and the discovery of high lead contents in some canned foods and other food products in Nigeria. Lead exposure and poisoning may be eradicated in the nearest future in Nigeria with greater awareness on its health implications, the use of cleaner fuel for cooking or heating, and with the proactive and collaborative approach by the government, parents, the Ministry of Health and Environment, the food industries, the paint manufacturing industries, and other stakeholders’ in the society. There is also the need to encourage the use of cleaner fuel in households. There is the possibility of future study on lead exposure in Nigerian children through the application of leaded beauty products such leaded eye pencils on their eyes by some mothers.
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Acceptability and Adequacy in Translation of John Steinbeck’s Novel by Soroush Habibi
This study examines a novel written by John Steinbeck and correspondingly its translation into Persian by Soroush Habibi (2009). Gideon Toury’s Acceptability, Adequacy and Cultural Norms (1995) have been applied in this study. The researcher gathered some information about Toury and his theory of “cultural norms”, and also the two types of translation, namely “adequate” and “acceptable” defined by the same scholar. The translated text was analyzed against the original work to determine if it is source-oriented (adequate) or receptor-oriented (acceptable). The impact of the ideology of the translator on adequacy and acceptability in translation has also been considered as the most important case in the study. The findings of the study revealed that Habibi’s translation was acceptable.
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An application of Weiner’s attribution theory to the self-perceived communication competence of Iranian intermediate EFL learners
This study examined the relationship between EFL learners’ attributions for success and failure in learning a foreign language and their self-perceived communication competence. To this end, having homogenized the learners via the Interchange Objective Placement Test (IOPT), the Causal Dimension Scale (CDS-II) and the Language Achievement Attribution Scale (LAAS) were administered to 72 EFL learners studying at two English language institutes in Iran. Six causal attributions (ability, effort, task difficulty, mood, luck, and teacher) together with four attributional properties (locus of causality, stability, personal control, and external control) were compared with learners’ self-perceived communication competence. To see whether there is any significant relationship between learners’ attributions and their self-perceived communication competence, Pearson product-moment correlation was applied to the data. The results showed significant correlations between some of the LAAS, but not CDS-II, subscales and learners’ scores on the SPCC scale. Results from Regression Analysis (using LAAS) revealed that task difficulty attribution was the best predictor for low SPCC scores, indicating that students who attributed the outcome of their test to the difficulty of the task received lower grades on the SPCC scale. Finally, statistical results were discussed, and implications for English language teaching were suggested.
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An examination of the link between corporate governance and organizational performance in the Nigerian banking sector
This paper examined the link between corporate governance and organisational performance in the banking industry. The objectives of this study were to investigate the significant difference between corporate governance practices and organisational performance and also to examine whether corporate governance variables used in this study were predictors of or were associated with organisational performance in the banking sector in Nigeria. The study employed survey research design. The subjects were employees of five banks in Oyo, Oyo State, Nigeria. Primary data was obtained through questionnaires to get opinions of employees in the five banks. Five hypotheses were formulated and tested using Correlation Analysis, Regression Analysis, and T-test. The findings showed that there was a significant difference between Corporate Governance practices and Organizational Performance. It was also shown that corporate governance policies, and Shareholder Right and responsibilities jointly predicted Organizational Performance. In addition, it was shown that there was significant relationship between Shareholder right and responsibilities and Organizational performance. Lastly, research found that corporate governance policies and corporate governance practices jointly predicted Organizational Performance. Based on the findings, it was recommended that the management and staff of the banks should make it a point of duty to understand the concept of corporate governance and carry along the various stakeholders with a view to improving organizational performance.
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An Improve Poisson Approximation For The Generalized Binomial Distribution With Financial Application
The aim of this study is to improve Poisson distribution for the approximation of a generalized binomial distribution and to combine the improved Poisson distribution with financial terms for the purpose of evaluating a European call and put option. It was found that the improved Poisson approximates generalized binomial when ? [ ], approximates generalized binomial sufficient enough n, B/A+B when and ? and also that the problem of option for non-dividend paying stock can be approached using an improved Poisson distribution function equipped with some financial terms. The .numerical results obtained is the same as in [4], using the numerical data. Relevant connections of our work with the earlier work is pointed out.
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Analysis of the automation telecommunication and how works it
The distribution automation system, should be the relationship between the different parts, this connection is performed by the telecommunication system. This study is based on a descriptive analysis and use of available resources to analyze automation telecommunication , and how it acted. Results indicated that collected information, tools and measuring equipment, as well as status indicators, this data includes voltage lines, switch status and key, and the temperature of the transformer and is, by means of relays digital, CT, PT, PI, or error detection, etc., collected, and for the electrical signal, is ready. The instrument is needed, to the various data collected, and ready to send. The device should be able to, such as terminal information act, and electrical signals different, the voltages and current levels vary in a range acceptable, and to send ready, and at the same time be able to signal receive operation also , to apply to the equipment, to reach the desired voltage level. The device, remote terminal units, or the so-called RTU, called. Telecommunication system, should be able to kind of adjustment between the data created. The data on the one hand, the path between the terminal and the control center to travel. Information, telecommunication system, some changes are to transfer from the environment to be prepared. These changes are known to act modulation. After sending the photo changes based on the signal, the signal becomes understandable message back into shape.
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Analyzing the factors influencing the emergence of India as world’s manufacturing hub
This short article addresses several prevailing issues evolving from the growth of Indian industries and portrays the prospective of India to be transformed into World’s manufacturing hub. Thereafter several criteria and sub-criteria are identified which are crucial in this regard. In order to understand the scope of India to turn out to be the potential manufacturing hub, a relative and comparative analysis has been carried out using a Multi Criteria Decision Analysis tool namely Analytic Hierarchy Process (AHP). The result obtained, demonstrates that India is an automatic choice as the hub of manufacturing, since all the important resources are available in abundance.
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Antagnostic effect of raze bacteria from the squat horned grasshoppers using (p-dimethylaminobenzaldehyde) and indole test
Bacterial antagonism is a phenomenon in which the growth and activity of other bacteria is inhibited. In general microorganisms produce secondary metabolites which are not as essential for the survival of the organism. The organism produces an inhibitory product may be an antibiotic which doesn’t allow the growth of other organisms. In this present study the bacteria are isolated from the gut of short horned grasshoppers and screened for antagonistic activity. A mixed population of bacteria was observed in the respective agar plates and was identified as Pseudomonas sp, Bacillus sp, Micrococcus and Escherichia coli. To test for antagonistic effect the gut isolated bacteria were tested against four human pathogenic bacteria Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli, Vibrio parahameolyticus and one yeast like fungus Candida albicans. It was observed that gut associated Pseudomonas sp had antagonistic activity against yeast like fungus Candida albicans and Escherichia coli. The most potent strain was subjected for 16srRNA gene sequencing in order to identify the antagonistic bacteria. The 16srRNA partial sequences have been run in the Bioinformatics tool, (BLAST) Basic Local Alignment search tool to find out the most similar sequences which matches with our strain. Phylogenetic tree has been constructed and our strain matches with Pseudomonas otitids which has (99.1%) similarity.
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