Physiology and Anatomy

Suitable clinical learning environment results in appropriate learning outcomes in clinical area. The objective was to analyse the influence of clinical environment on clinical learning. Cross sectional research design was used. Study targeted 200 participants sampled purposively. Data was recorded in SPSS version 21.0 and analysed using t-test for means. Statistical significance was determined at p=0.01 the data was presented in form of tables. The study found that clinical placement (p=0.015), and length of clinical attachment (p=0.04) were predictors of clinical learning. The study recommends teaching facilities to establish appropriate schedule for clinical placements in order to enhance clinical learning.

The aim of this paper is to evaluate current regulatory guidelines for clinical research, drug development and the evolution and reforms in current and evolving practices in the United States, and Canada, with a detailed focus on India’s regulatory reforms and growing market. The United States is the largest pharmaceutical market, and the epicenter of clinical trials and research. Canada is the world’s second largest center of clinical trials and has pioneered many discoveries in diabetes care. India is gaining ground in clinical research with strengths in research, large drug manufacturing capabilities, world class hospital and medical facilities and infrastructure. The proficiencies of researchers in English, good clinical skills, a large population and prevalence of most disease types in India’s are also reasons for its position in clinical research and a favorable destination. India’s regulators have undertaken reforms of regulatory requirements to improve processes and ensure consistency with international standards. The over reliance by the Indian pharmaceutical industry on generics in sustainability and future growth of the industry may be dampened as the inevitable crowded space by international competitors and other manufacturers will likely cause ceding of some market share. Utilizing the immense talents in new drug development may provide new areas of economic opportunities. The promise for developing innovative and next generational products and marketing are immense. Continued investment in quality, discovery, achieving parity with international regulatory standards will expectedly fulfill great expectations and the inarguable tremendous potential India holds. The regulatory affairs and drug development discussion in India is further related to Type 2 Diabetes in India, as the incidence of Type 2 Diabetes is escalating exponentially worldwide and needs urgent therapeutic and management solutions.

Background and objectives Length of the ring finger is more as compared to the index finger in males and they are almost equal in females. The ratio between 2D:4D is less in males (<1) but in females it is more (>1). This is directly related to exposure of more testosterone during intrauterine life of the fetus. The persons who are having 2D:4D ratio less than one are more aggressive and masculine characters. The present study is to find out the aggressive behavior of the persons and its relation to ratio of index finger length and ring finger length. (2D:4D). Methodology Fifty male and fifty female medical students in the age group ranging from 19 to 25 years studying in first year M.B.B.S. were selected. The students were selected randomly. The 2D and 4D length were taken and the ratio between them is calculated. The aggressive questionnaire was administered according to Aggression Questionnaire. Results Of the four types of aggression physical, anger and verbal was more seen in males (Scale T-score >55) as compared to hostility that was more in females (>55) but statistically not significant (p=0.422). Conclusion The co-relation between 2D:4D length ratio and aggressive behavior of the subjects was not significant statistically (P = 0.217).

Anomalous pulmonary venous connection is an abnormality in the blood flow in which all the 4 pulmonary veins drain into the systemic veins or into the right atrium with or without the pulmonary venous obstruction. The Systemic and the pulmonary venous blood get mix in the right atrium. Becomes an atrial defect or foramen ovale is more important in the left ventricular output as both in the fetal and in the newborn circulations

As the scrotum and labia majora form in males and females, respectively; the gubernaculum aids in the descent of the gonads. This being both testes and ovaries. The testes would descend to a greater degree than the ovaries and thus passing through the inguinal canal. The gubernaculum connects the gonad to the inguinoscrotal region and is involved in testis descent. In the male fetus it rapidly develops, whereas in the female fetus, development is lacking.

Autoimmune pancreatitis is a rare form of chronic pancreatitis. There are two diffuse and focal forms that mimic the appearance of a pseudo-mass or pancreatic adenocarcinoma, which the differential diagnosis may be difficult, The classic CT scan appearance of AIP is that of diffuse hypertrophy of the sausage shaped pancreas and a pathognomonic hypodense peripheral ring with a delayed contrast enhancement, Focal pancreatic involvement is often seen in the head of the pancreas and appears in the form of a mass mimicking pancreatic adenocarcinoma.

Bladder tumors remain rare in young people. Tobacco is an important risk factor. The evolutionary profile of superficial tumors seemed to us different before and after 30 years. Tobacco is an important factor in the genesis of these tumors, but other factors may be hereditary. Their profile is still poorly known. The objective of this work is to:Specify the risk factors in this type of population.Define the characteristics of these tumors. Attempt to determine the evolutionary profile after treatment.

Majority of tumours occurring in minor salivary gland are malignant. Pleomorphic adenoma is a benign tumour rare in minor salivary gland of palate. We report a rare case of a minor salivary gland pleomorphic adenoma of the palate in 60 year old female patient who presented with painless slow progressive swelling of palate over the last 7 years. The mass was extending to nasopharynx and oropharynx causing mechanical obstruction of airway and dysphagia. CT scan depicted soft tissue density mass lesion measuring 5 × 4.5cm in the left half of soft palate. Fine needle aspiration cytology was suggestive of pleomorphic adenoma. Complete surgical excision of mass was done. Histopathological examination confirmed diagnosis of pleomorphic adenoma of minor salivary gland. Pleomorphic adenoma must be considered in the differential diagnosis of palatal mass. Timely intervention of pleomorphic adenoma prevents malignant changes.Complete surgical excision is the treatment of choice.Recurrence is rare after complete surgical excision with wide margin. Prognosis is excellent after complete surgical excision.

The forgetfulness of foreign body after digestive and abdominal surgery, despite its rarity, remains a real challenge. Justifying the reputation of textilomas known as being difficult to diagnose. Training is needed to try to reduce this rare but serious complication. We report a series of 5 cases of abdominal and digestive tract textilomas collected over a period of 5 years in the department of visceral surgery and oncology of Oujda university hospital, with review of the literature on this issue.

The Buschke-Löwenstein tumor (TBL) or giant acuminate condyloma (GAG) is a pseudo-epitheliomatous proliferation belonging to the group of verrucous carcinomas. Its first description dates back to 1896. It was in 1925 that Buschke and Löwenstein made it a characteristic entity. It is of viral origin (HPV), of sexual transmission reaching mainly the ano-genital zones. It is characterized by its degenerative potential and its recurrence after treatment. TBL is a relatively rare condition and always preceded by condylomata acuminata, its annual incidence appears to be 0.1% among the sexually active adult population. It occurs at any age after puberty and predominates between the 4th and 6th decades. The infection can reach both sexes, it is frequently seen in the male sex. The development, persistence and recurrence of condylomas largely reflect the immune status of the host. Immunosuppression, chronic inflammation, lack of hygiene and HIV infection appear to be risk factors for this condition. The implication of the papillomavirus and in particular of its serotypes HPV 6 and 11 is accepted in the genesis of the TBL. Its prevention is imperative based on the treatment of condylomata acuminata and the fight against sexually transmitted diseases. The treatment must be early, it is essentially surgical requiring a wide excision. We report the case of a 55-year-old patient with a history of sexual vagrancy and repeated urethritis who consults for a penile tumor that has been evolving for 8 years. The clinical examination noted several infiltrated tumor lesions, cauliflower papillomatous lesions of the root and ventral surface of the penis, fetid and painless. The ganglionic areas were free. HIV, syphilitic and hepatitis B and C serology were negative. Treatment consisted of surgical excision with skin covering adjacent to the skin. The histological examination of the excision piece revealed an important papillomatous hyperplasia of the epidermis and some koilocytes in favor of a giant condyloma. After 2 years of retreat, we did not find any recurrence.